[2T04] Proteins 03

1:19 PM - 1:28 PM JST(4:19 AM - 4:28 AM UTC)

[2T04-02] Elucidation of the molecular mechanism by which SNIPER(ABL) induces both proteasomal and lysosomal degradation

^○Sota Hashimoto^1,2, Yoshinori Tsukumo³, Nobumichi Ohoka³, Akinori Endo⁴, Fumiaki Ohtake⁵, Yasushi Saeki⁶, Shigeo Murata^1,2, Mikihiko Naito^1,3 (1.Laboratory of Targeted Protein Degradation, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2.Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3.National Institute of Health Sciences, 4.Tokyo Metropolitan Institute of Medical Science, 5.Hoshi University, 6.The Institute of Medical Science,The University of Tokyo)

キーテクノロジー：生化学

Keywords:

PROTAC/SNIPER、標的タンパク質分解技術、ユビキチン、プロテアソーム、リソソーム

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