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Presentation Information

Session Details

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Program Type

Optimizations and applications of PUP-IT proximity labeling

How, when, where, and why do genes and proteins behave the way they do? With what molecules do the gene and the protein of interest interact? These are very important questions for understanding the molecular mechanism underlying the biological phenomena. To answer these questions, it is indispensable to develop technologies that enables us to label and analyze the target biomolecules specifically. In this symposium, the speakers will present their latest research in molecular labeling technologies for biomolecular interactions, for proteomics analysis of specific membrane regions, and live cell imaging with high spatiotemporal resolution. Two proximity labeling techniques described here (PUP-IT and SplitTurbo ID) have contributed to the identification of novel binding proteins in immune and brain cells that have not been found by previous biochemical methods. High-resolution live imaging of the genome and transcription factors has made it possible to reveal the process of gene transcription activation with great spatiotemporal accuracy. Furthermore, the speakers will report the latest methods to label proteins and organelles on the cell membrane by chemical covalent bonding. We aim that the discussion between speakers and the audience will provide novel insight into the research of many audiences.

日本分子生物学会年会

The 45th Annual Meeting of the Molecular Biology Society of Japan

The 45th Annual Meeting of the Molecular Biology Society of Japan

[1AS-02-2]Optimizations and applications of PUP-IT proximity labeling

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