[1AS-02] 【J】Aging and Pathology Induced by Genome Stress and Metabolic Aberrations

10:13 AM - 10:33 AM JST(1:13 AM - 1:33 AM UTC)

[1AS-02-06] The Rubicon-WIPI axis regulates exosome biogenesis during aging

○Kyosuke Yanagawa^1,2, Akiko Kuma^1,3, Maho Hamasaki^1,4, Shunbun Kita^5,6, Tadashi Yamamuro⁷, Kohei Nishino⁸, Shuhei Nakamura⁹, Hiroko Omori¹⁰, Tatsuya Kaminishi^1,11, Satoshi Oikawa⁷, Yoshio Kato¹², Ryuya Edahiro^13,14, Ryosuke Kawagoe¹⁵, Takako Taniguchi¹⁵, Yoko Tanaka¹⁶, Takayuki Shima⁹, Keisuke Tabata¹⁷, Miki Iwatani¹, Nao Bekku¹, Rikinari Hanayama^18,19, Yukinori Okada^{13,20,21,22,23}, Takayuki Akimoto²⁴, Hidetaka Kosako⁸, Akiko Takahashi¹⁶, Iichiro Shimomura⁵, Yasushi Sakata², Tamotsu Yoshimori^1,3,4,11 (1. Department of Genetics, Graduate School of Medicine, Osaka University, 2. Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, 3. Health Promotion System Science, Graduate School of Medicine, Osaka University, 4. Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences Osaka University, Osaka University, 5. Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 6. Tokyo New Drug Research Laboratories, Pharmaceutical Business Unit, Kowa Company Ltd, 7. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 8. Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 9. Department of Biochemistry, Nara Medical University, 10. Research Institute for Microbial Diseases, Osaka University, 11. Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 12. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 13. Department of Statistical Genetics, Osaka University Graduate School of Medicine, 14. Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, 15. i2i-Labo, Central Pharmaceutical Research Institute Yokohama Research Center, JT inc., 16. Division of Cellular Senescence, The Cancer Institute, Japanese Foundation for Cancer Research, 17. Department of Physiology, Juntendo University School of Medicine , 18. Department of Immunology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 19. WPI Nano Life Science Institute (NanoLSI), Kanazawa University, 20. Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, 21. Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, 22. Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, 23. Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, 24. Laboratory of Muscle Biology, Faculty of Sport Sciences, Waseda University)

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