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Comprehensive profiling of genomic structural variants and aberrant cytosine methylation of cancer genome using long-read sequencing

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Throughout life, living organisms use the genomic DNA within their cells to carry out genetic programs. Genomic DNA is constantly exposed to various internal and external stresses and is damaged, which is repaired to maintain cell function. However, excessive DNA damage not only causes cell death, but even after the damage is repaired, it induces cellular senescence and genomic mutations leading to cancer. This symposium will focus on DNA damage, which is a common molecular mechanism in organismal development and disease, and introduce research that makes full use of cutting-edge next-generation technologies such as long-read sequencing, next-generation sequencing, single-cell analysis, spatial analysis, innovative imaging technology, and genome editing. Based on these studies, we would like to deepen our understanding of the DNA life cycle in biological phenomena and discuss its significance.<br>

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[1AS-11-06]Comprehensive profiling of genomic structural variants and aberrant cytosine methylation of cancer genome using long-read sequencing

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