[3P-899]PRMT1 promotes chemoresistance in triple-negative breast cancer by methylating metabolic enzymes PFKFB3, PKM2, and PHGDH to augment de novo fatty acid synthesis.
○Takehiro Yamamoto1, Tetsu Hayashida2, Yohei Masugi3, Mai Itoh1,4, Takako Hishiki1, Chiyoko Nishime4, Naoharu Takano5, Kenichi Horisawa6, Makoto Suematsu1,4(1. Dept. of Biochem., Sch. of Med., Keio Univ, 2. Dept. of Surg., Sch. of Med., Keio Univ., 3. Dept. of Pathol., Sch. of Med., Keio Univ., 4. Central Institute of Experimental Medicine, 5. Dept. of Biochem., Sch. of Med., Tokyo Medical. Univ., 6. Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University)
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