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Wed. Dec 3, 2025

Thu. Dec 4, 2025

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PIWI-piRISC assembly defect underlying infertility: insights from <em>Drosophila</em> and mouse models

Transposons have long been thought to account for approximately 40% of the human genome. However, the Telomere-to-Telomere (T2T) Consortium recently revealed that this proportion reaches 53%. This groundbreaking discovery highlights the “peculiar" symbiotic relationship between humans (and other host organisms) and transposons spanning hundreds of millions of years, heralding a new era of transposon research. What is the true purpose of transposons co-existing in the genome? How have we, as hosts, managed to accommodate, control, and even harness their selfish nature for our benefit? Could transposons hold the potential as a novel modality for drug discovery? In this symposium, researchers exploring transposons from diverse perspectives will come together to share cutting-edge insights and engage in discussions with the audience on these fascinating questions.

【E】Transposons and Hosts: Symbiosis, Evolution, and Prospects

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[1AS-02-01]PIWI-piRISC assembly defect underlying infertility: insights from Drosophila and mouse models

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