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Wed. Dec 3, 2025

Thu. Dec 4, 2025

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Smarcad1 facilitates the mismatch-repair-dependent <em>O</em><sup>6</sup>-methylguanine response during DNA replication

DNA replication is a highly accurate process; nevertheless, it also enables evolution by "tolerating errors." This symposium will discuss how cells adapt to DNA replication stress derived from fluctuations in the chromatin environment and exhibit replication robustness by regulating repair and alternative replication systems. We will also focus on how replication robustness prioritizes replication completion and contributes to the "trade-off" between cell survival and genome/epigenome integrity under replication stress.

【J】Replication Stress and Robustness: A Balancing Act in Genomes

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[2AS-06-05]Smarcad1 facilitates the mismatch-repair-dependent O⁶-methylguanine response during DNA replication

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[2AS-06-05]Smarcad1 facilitates the mismatch-repair-dependent O6-methylguanine response during DNA replication

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[2AS-06-05]Smarcad1 facilitates the mismatch-repair-dependent O⁶-methylguanine response during DNA replication