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ApoE4 in Vascular Mural Cells and Brain Homeostasis

The APOE4 is the highest genetic risk factor for sporadic Alzheimer's disease. The frequency of the APOE4 allele is high in the general population. Thus, there is a significant impact on Alzheimer's disease. Elucidating the role of APOE4 in the pathogenesis of Alzheimer's disease would be important. It may also lead to the treatment of Alzheimer's disease that does not associate with APOE4. However, the involvement of APOE4 in the pathogenesis of the Alzheimer's disease has long been shrouded in mystery. Nearly 30 years after its discovery, new aspects for APOE4 participation in Alzheimer's disease's pathogenesis have recently come to light. In this symposium, we will present the remarkable recent advances in the involvement of APOE4 in the pathogenesis of Alzheimer's disease, and we hope to give the audience a sense of the trends in this area of research.

Annual Meeting of the Japanese Society of Neurology

NEURO62

NEURO62

[NFS-03-3]ApoE4 in Vascular Mural Cells and Brain Homeostasis

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