[P002]Nsp2 and Nsp3 Create the Virulence Differences between SARS-CoV1 and SARS-CoV2
○Yiyuan Liu1, Jiahuai Han1
(1. Xiamen University (China))
Wed. Sep 18, 2024 4:50 AM - 5:50 AM UTC
○Yiyuan Liu1, Jiahuai Han1
(1. Xiamen University (China))
○Stella Foriwaa Bour1, Magdalene Ofori1, Deborah Pratt1, Selassie Kumordjie2, Bright Agbodzi2, Dennis Laryea4, Franklin Asiedu-Bekoe4, Takaya Hayashi3, Toshihiko Suzuki3, Joseph Humphrey Bonney1
(1. Noguchi Memorial Institute for Medical Research, University of Ghana (Ghana), 2. US Naval Medical Research Unit-No.3, Ghana Detachment (Ghana), 3. Tokyo Medical and Dental University (Japan), 4. Public Health Division, Ghana Health Service, Ministry of Health (Ghana))
○Yutaro Yamagata1, Lay Myint Yoshida1
(1. Institute of Tropical Medicine, Nagasaki University (Japan))
○Naoto Koyanagi1, Akihisa Kato1, Kosuke Takeshima1, Yuhei Maruzuru 1, Yasushi Kawaguchi1
(1. Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo (Japan))
○Kanako Terakado Kimura1, Hisano Yajima1, Sateki Suzuki1, Yuki Anraku2, Yukihiko Sugita3, Shunsuke Kita2, JX-Vir ., Takeshi Noda3, Katsumi Maenaka2, G2P-Japan ., Kei Sato4, Takao Hashiguchi1
(1. Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University (Japan), 2. Laboratory of Biomolecular Science and Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University (Japan), 3. Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University (Japan), 4. Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo (Japan))
○Hirotake Kasai1, Kohji Moriishi1
(1. Institution: Department of Microbiology, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi (Japan))
○Yuki Iwaisako1, Tadashi Watanabe2, Youichi Suzuki3, Takashi Nakano3, Masahiro Fujimuro1
(1. Kyoto Pharmaceutical University (Japan), 2. University of the Ryukyus (Japan), 3. Osaka Medical and Pharmaceutical University (Japan))
○Hayato Matsuoka1,2, Naoki Uno1, Hiroshi Nishiura2
(1. Nagasaki University Graduate School of Biomedical Sciences Department of Medical Virology (Japan), 2. Kyoto University School of Public Health (Japan))
○Yu Kaku1, Yusuke Kosugi1, Keiya Uriu1, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Jumpei Ito1, Kei Sato1
(1. Division of Systems Virology, the Institute of Medical Science, the University of Tokyo (Japan))
○Min-Ren Zhang1, Peng Lu1, Ai-Ai Chou1, Wei-Tao Chang1,2, Po-Yao Huang2, Chung-Hui Lin1,2, Hui-Wen Chen1
(1. Natl Taiwan Univ. (Taiwan), 2. TACS-Alliance Research Center (Taiwan))
○Jing-Yuan Chen1,2, Meng-Chi Wu1, Zih-Syun Fang1, Che-Ming Hu3, Hui-Wen Chen1,2
(1. DVM, NTU (Taiwan), 2. ARC, NTU (Taiwan), 3. IBMS, AS (Taiwan))
○Mansaku Hirai1, Jing Rin Huang1, Salma Aktar1, Yasuko Mori1, Jun Arii1
(1. Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine (Japan))
○Meng-Chi Wu1,2, Ryo Komorizono1, Jing-Yuan Chen4, Ai-Ai Chou4, Madoka Sakai1, Akiko Makino1,2, Takehiro Kanda1,3, Hui-Wen Chen4, Keizo Tomonaga1,2,3
(1. Laboratory of RNA viruses, Institute for Life and Medical Sciences, Kyoto University (Japan), 2. Laboratory of RNA viruses, Graduate School of Biostudies, Kyoto University (Japan), 3. Department of Molecular Virology, Graduate School of Medicine, Kyoto University (Japan), 4. Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan (Taiwan))
○AILA GULIJIAHANI1, Jun Arii1, Jing Rin Huang1, Yasuko Mori1
(1. Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine (Japan))
○Yoshihiko Tanimoto1,2, Ai Mori2, Ryohei Nomoto2
(1. Institute for Life and Medical Sciences, Kyoto University (Japan), 2. Department of Infectious Diseases, Kobe Institute of Health (Japan))
○Madoka Sakai1, Yu Ishikawa-Yamauchi2, Akiko Makino1,3, Takehiko Ogawa2, Keizo Tomonaga1,3,4
(1. Laboratory of RNA Viruses, Institute for Life and Medical Sciences, Kyoto University (Japan), 2. Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University (Japan), 3. Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University (Japan), 4. Department of Molecular Virology, Graduate School of Medicine, Kyoto University (Japan))
○HAOKUN LI1, HIKARU NAMBA1, HIROHITO OGAWA1, HIROKAZU KATOH1, TOMOYUKI HONDA1
(1. Development of Virology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University (Japan))
○Haruka Abe1, Nga Thi Nguyen1, Thuy Thu Thi Nguyen2, Mai Thi Quynh Le2, Futoshi Hasebe1
(1. Nagasaki University (Japan), 2. National Institute of Hygiene and Epidemiology (Viet Nam))
○Pei Wang1, Gabriele Neumann2, Shintaro Shichinohe1, Le Thi Quynh Mai3, Yoshihiro Kawaoka2,4,5,6, Tokiko Watanabe1,7,8
(1. Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University (Japan), 2. Influenza research Institute, University of Wisconsin-Madison (United States of America), 3. National Institute of Hygiene and Epidemiology, Hanoi 100000 (Viet Nam), 4. Department of Virology, Institute of Medical Science, University of Tokyo (Japan), 5. The University of Tokyo Pandemic Preparedness, Infection and Advanced research center (UTOPIA), University of Tokyo (Japan), 6. The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo (Japan), 7. Center for Infectious Disease Education and Research (CiDER), Osaka University (Japan), 8. Center for Advanced Modalities and DDS (CAMaD), Osaka University (Japan))
○Tateki Suzuki1, Yusuke Yanagi2, Takao Hashiguchi1
(1. Institute for Life and Medical Sciences, Kyoto University (Japan), 2. Kyushu University (Japan))
○Shinya Goto1,2, Yuya Hirai3, Keizo Tomonaga4,5,6, Takeshi Noda1,2, Masayuki Horie7,8, Yukihiko Sugita1,2,9
(1. Laboratory of Ultrastructural Virology, Graduate School of Biostudy, Kyoto University (Japan), 2. Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University (Japan), 3. Department of Biology, Osaka Dental University (Japan), 4. Laboratory of RNA viruses, Institute for Life and Medical Sciences, Kyoto University (Japan), 5. Laboratory of RNA Viruses, Graduate School of Biostudy, Kyoto University (Japan), 6. Laboratory of Molecular Virology, Graduate School of Medicine, Kyoto University (Japan), 7. Laboratory of Veterinary Microbiology, Graduate School of Veterinary Science, Osaka Metropolitan University (Japan), 8. Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University (Japan), 9. Hakubi Center for Advanced Research, Kyoto University (Japan))
○Katsuhisa Hirai1, Yuta Kanai1, Zelin Chen1, Shohei Minami1, Tomohiro Kotaki1, Takeshi Kobayashi1,2,3
(1. Department of Virology, Research Institute for Microbial Diseases, Osaka University (Japan), 2. Center for Infectious Disease Education and Research, Osaka University (Japan), 3. Center for Advanced Modalities and DDS, Osaka University (Japan))
○Yuta Toritani1, Yuki Iwaisako1, Suzuki Youichi2, Takashi Nakano2, Masahiro Fujimuro1
(1. Kyoto Pharmaceutical University (Japan), 2. Osaka Medical and Pharmaceutical Univ. (Japan))
○Haruka Shikai1, Yuki Iwaisako1, Masahiro Fujimuro1
(1. Kyoto Pharmaceutical University (Japan))
Yoko Fujita-Fujiharu1,2,3,4, ○Shangfan Hu1,2,3,5, Ai Hirabayashi1,3, Yuki Takamatsu5, Yen ni Ng1,2,3, Kazuya Houri1,2,3, Yukiko Muramoto1,2,3, Masahiro Nakano1,2,3, Yukihiko Sugita1,2,6, Takeshi Noda1,2,3
(1. Lab of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto Univ (Japan), 2. Lab of Ultrastructural Virology, Graduate School of Biostudies, Kyoto Univ. (Japan), 3. CREST, Japan Science and Technology Agency (Japan), 4. Department of Cell and Virus Structure, Max-Planck-Institute of Biochemistry (Germany), 5. Department of Virology, Institute of Tropical Medicine, Nagasaki University (Japan), 6. Hakubi Center for Advanced Research, Kyoto Univ. (Japan))
○Yingying Zhang1
(1. Xiamen University, China (China))
○Betty Kathomi Muriithi1, Satoshi Kaneko1, Violet Wanjihia3, Tonomori Hoshi2, Samson Muoo4, Taeko Moriyasu5, Kazuchiyo Miyamichi2, Junichi Tanaka5, Mohammed Karama1, Christine Bii4, Zipporah Bukania3, Sheru Wanyua1, Morris Ndemwa1
(1. Nagasaki University Institute of Tropical Medicine-Kenya Medical Research Institute (NUITM-KEMRI) Project (Kenya), 2. Nagasaki University Institute of Tropical Medicine (Japan), 3. Center for Public Health Research-Kenya Medical Research Institute (Kenya), 4. Center for Microbiology Research-Kenya Medical Research Institute (Kenya), 5. Nagasaki University (Japan))
○Sarunporn Tandhavanant1,2, Thatcha Yimthin1, Sineenart Sengyee1,3, Ratana Charoenwattanasatien4,5, Andrey A. Lebedev6, Eric R. Lafontaine7, Robert J. Hogan7,8, Claire Chewapreecha9,10, T. Eoin West11,12, Toshio Kodama2, Paul J. Brett1,3, Mary N. Burtnick1,3, Narisara Chantratita1,9
(1. Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University (Thailand), 2. Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University (Japan), 3. Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, NV (United States of America), 4. Beamline Division, Synchrotron Light Research Institute, (Public Organization) (Thailand), 5. Center for Biomolecular Structure, Function and Application, Suranaree University of Technology, (Thailand), 6. CCP4, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot OX11 0FA (UK), 7. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA (United States of America), 8. Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA (United States of America), 9. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University (Thailand), 10. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University (Thailand), 11. Division of Pulmonary, Critical Care and Sleep medicine, Department of Medicine, University of Washington, Seattle, WA (United States of America), 12. Department of Global Health, University of Washington, Seattle, WA (United States of America))
○Hoan T Pham1,2, Hirotaka Hiyoshi2, Toshio Kodama2
(1. Grad Sch Biomed Sci, Nagasaki Univ, Japan (Japan), 2. Dept Bacteriology, Inst Trop Med, Nagasaki Univ, Japan (Japan))
Mei-Chen Tan1, Pei-Jing Chen1, I-Wen Huang1, Jui-Fen Lai1, Hui-Ying Wang1, ○Shu-Chen Kuo1
(1. National Health Research Institutes (Taiwan))
○Chia-Yu Chi1,2, Yao-Jong Yang3, Fan-Ching Shen1, Chien-Shun Chiou4, Po-Line Chen5, Pei-Fang Tsai6, Yun-Ju Lee1
(1. National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes (Taiwan), 2. Department of Microbiology & Immunology, College of Medicine, National Cheng Kung University (Taiwan), 3. Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University (Taiwan), 4. Center for Diagnostics and Vaccine Development, Centres for Disease Control (Taiwan), 5. Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University (Taiwan), 6. Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University (Taiwan))
○Caroline Wangui Njoroge1, John Gachohi2, Joseph Mutai1, Ann Wanjiru Mwangi1, Tonny Teya Nyandwaro1, Mathew Munyao Mutinda1, Robinson Irekwa Mugasiali1, Peter Kipkemboi Rotich1, Joanne Jepkemei Yego1, Grace Ng'endo Kanyitta3, Samson Muuo Nzou1
(1. Kenya Medical Research Institute (Kenya), 2. Jomo Kenyatta University of Agricuture and Technology (Kenya), 3. Kenyatta University (Kenya))
○Ruofan PENG1, Herbert Santos1, Tomoyoshi Nozaki1
(1. Department of International Health, Graduate of Medicine, the University of Tokyo (Japan))
○ABUL HASAN SARDAR1
(1. Department of Microbiology, Sarsuna College (University of Calcutta) (India))
○Nattawat Chaiyawong1,2,3,4, Takahiro Ishizaki3,4,5, Deepti Sarkar1, Osamu Kaneko3,4, Prakash Srinivasan1,6
(1. Department of Molecular Microbiology and Immunology and The Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, MD (United States of America), 2. Siriraj Integrative Center for Neglected Parasitic Diseases, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok (Thailand), 3. Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki (Japan), 4. Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki (Japan), 5. Parasitology and Zoology Unit, Department of Infection and Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido (Japan), 6. correspondence: psriniv3@jhu.edu (United States of America))
Natalia Yuwono1, Soraya Salle Pasulu2, ○Binarri Augustya3,4, Fitriah Fitriah4, Lynda Rossyanti3,4, Suhintam Pusarawati3,4, Dominicus Husada5, Sukmawati Basuki3,4, Yoes Prijatna Dachlan3
(1. Faculty of Medicine, Universitas Ciputra, Surabaya (Indonesia), 2. Department of Child Health, Sorong District Hospital/Faculty of Medicine, Universitas Papua, Sorong, Southwest Papua (Indonesia), 3. Department of Medical Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya (Indonesia), 4. Malaria Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya (Indonesia), 5. Department of Child Health, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya (Indonesia))
○Kentaro Morita1, Yoshio Osada1, Shoichi Shimizu1
(1. University of Occupational and Environmental Health, Japan (Japan))
○Yu Nakagama1, Susana Peña2, Shun Nakagama1, Katherine-Sofia Candray-Medina3, Roberto Leonel Ayala Minero2, Sachie Nakagama1, Carmen Elena Arias3, Maricela Mejía3, Karla Marina Alas3, Rosa Maria Guerrero3, Yuko Nitahara1, Junko Nakajima-Shimada4, Yasutoshi Kido1
(1. Department of Parasitology, Graduate School of Medicine, Osaka Metropolitan University (Japan), 2. National Rosales Hospital (El Salvador), 3. Centro Nacional de Investigaciones Científicas de El Salvador (CICES) (El Salvador), 4. Department of Molecular and Cellular Parasitology, Graduate School of Health Sciences, Gunma University (Japan))
○Takahiro Ishizaki1,2, Nattawat Chaiyawong2,3,4, Thant Zin Tun2, Miako Sakaguchi5, Masahito Asada2,6, Fuyuki Tokumasu7, Kazuhide Yahata2,8, Prakash Srinivasan4, Osamu Kaneko2
(1. Parasitology and Zoology Unit, School of Veterinary Medicine, Rakuno Gakuen University (Japan), 2. Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University (Japan), 3. Siriraj Integrative Center for Neglected Parasitic Diseases, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University (Thailand), 4. Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University (United States of America), 5. Central Laboratory, Institute of Tropical Medicine (NEKKEN), Nagasaki University (Japan), 6. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine (Japan), 7. Department of Laboratory Sciences, Graduated School of Health Sciences, Gunma University (Japan), 8. Division of Molecular Parasitology, Proteo-Science Center, Ehime University (Japan))
Mimie Bitshi1,2,3,4, Tomoyo Sakata-Kato1, Taeko K Naruse1, Héritier Zuau3, Papy Mandoko Nkoli3, Natsuko Kaku5, Yu Nakagama5, Yasutoshi Kido5, Dieudonné Mumba Ngoyi3,4, ○Osamu Kaneko1
(1. Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University (Japan), 2. Program for Nurturing Global Leaders in Tropical and Emerging Infectious Diseases, Graduate School of Biomedical Sciences, Nagasaki University (Japan), 3. Department of Parasitology. National Institute of Biomedical Research (Democratic Republic of the Congo), 4. Department of Tropical Medicine, University of Kinshasa (Democratic Republic of the Congo), 5. Department of Medical Science, School of Medicine, Osaka Metropolitan University (Japan))
○Maryam Shojaei1, Anthony Maclean, Sam Orde, Ben Tang, Klaus Schughart
(1. Senior Clinical fellow (Australia))
○Nuo Liu1,2,3, Ting Hua1,2,3, Ziyan Wan1,2,3, Junming Cao1,2,3, Xiaolong Li1,2,3
(1. Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui (China), 2. Key Laboratory of Immune Response and Immunotherapy, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, Anhui (China), 3. MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, Anhui (China))
○Keiko Shibata1, Harune Moriizumi1, Koji Onomoto2, Yuka Kaneko1, Mitsutoshi Yoneyama2, Kumiko Ui-Tei3, Tomoko Takahashi1
(1. Saitama Univ. (Japan), 2. Chiba Univ. (Japan), 3. Univ. Tokyo (Japan))
○Jordan Villa1, Tatsuhiko Ikeda1, Sho Miyamoto2, Tadaki Suzuki2, Kazuo Yamashita1
(1. KOTAI Biotechnologies, Inc (Japan), 2. National Institute of Infectious Diseases, Department of Pathology (Japan))
○Tatum Melati Andini1,2, Arthur Millius2, Daron Standley1,2, Soyoung Park1,2
(1. Research Institute of Microbial Disease, Graduate School of Medicine Osaka University (Japan), 2. Immunology Frontier Research Center, Osaka University (Japan))
○Yoshihiko Kuchitsu1, Kojiro Mukai1, Satoshi Waguri2, Tomohiko Taguchi1
(1. Tohoku university,Graduate school of Life Sciences (Korea), 2. Department of Anatomy and Histology, Fukushima Medical University School of Medicine (Japan))
○Yutaro Shirasaka1, Fumihiko Takeuchi1, Hiroki Kato2, Takashi Fujita1,2
(1. Laboratory of Regulatory Information, Institute for Life and Medical Sciences (LiMe), Kyoto University (Japan), 2. Institute of Cardiovascular Immunology, University of Bonn (Germany))
Jonas Søndergaard1, Janyerkye Tulyeu1, David Priest2, Shimon Sakaguchi3,4, ○James Badger Wing1,2,5
(1. Human single cell immunology team, CiDER, Osaka University (Japan), 2. Laboratory of Human Single Cell Immunology, WPI-IFReC, Osaka University (Japan), 3. Laboratory of Experimental Immunology, WPI-IFReC, Osaka University, (Japan), 4. Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University (Japan), 5. Center for Advanced Modalities and DDS (CAMaD), Osaka University (Japan))
○Qichao Chen1
(1. Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University (China))
○YU-SHENG LO1, Ming-Ju Hsieh2
(1. Oral Cancer Research Center, Changhua Christian Hospital, Changhua City (Taiwan), 2. Doctoral Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University, Taichung City (Taiwan))