The 13th Annual Meeting of the Asian Organization for Crohn’s and Colitis（AOCC2025）
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Session Details

Oral PresentationOral Presentaion

Oral Oresentation 16

Fri. Jul 11, 2025 3:30 PM - 4:48 PM JST
Fri. Jul 11, 2025 6:30 AM - 7:48 AM UTC
Room Ⅵ(Makuhari Messe Meeting Room 105)
Chair:Masayuki Fukata, Tomohisa Sujino
3:30 PM - 3:36 PM JST(6:30 AM - 6:36 AM UTC)

[O16-01]Bone Morphogenetic Protein 9 Stabilizes Gut Vascular Barrier in Refractory Ulcerative Colitis

*Shan Li1, Xingyue Zhou1, Yili Wang1, Bingyue Yao1, Jiayi Tu1, Siyuan Zhu1, Ritian Lin1, Qinjuan Sun1, Jinlai Lu1, Lan Zhong1 (1. Shanghai East Hospital Affiliated to Tongji University)
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3:36 PM - 3:42 PM JST(6:36 AM - 6:42 AM UTC)

[O16-02]Single cell transcriptomic analysis reveals insights into immunosenescence in the progression of ulcerative colitis

*Yang Zhang1,2, Jun Xu1,2, Shan Cao1,2, Yiken Lin1,2, Yulan Liu1,2 (1. Department of Gastroenterology, Peking University People’s Hospital, 2. Clinical Center of Immune-Mediated Digestive Diseases, Peking University People’s Hospital)
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3:42 PM - 3:48 PM JST(6:42 AM - 6:48 AM UTC)

[O16-03]Succinate drives gut inflammation by promoting FoxP3 degradation through a molecular switch

*Deyu Fang1 (1. Northwestern University)
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3:48 PM - 3:54 PM JST(6:48 AM - 6:54 AM UTC)

[O16-04]Causal Effects of Ulcerative Colitis on Immune-Mediated Inflammatory Diseases in Japanese Population: A Mendelian Randomization Study

*AYAKO FUCHIGAMI1 (1. Nippon Koukan Hospital)
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3:54 PM - 4:00 PM JST(6:54 AM - 7:00 AM UTC)

[O16-05]Impact of Hypercoagulable State on Crohn’s Disease Severity and Progression: Transcriptomic and Single-Cell Analyses of the Ileum

*Fengfei Wu1, Fangting Wu1, Hui Yang1 (1. Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China)
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4:00 PM - 4:06 PM JST(7:00 AM - 7:06 AM UTC)

[O16-06]Lactobacillus rhamnosus GG derived p40 protein restrains immune checkpoint inhibitor-related colitis by limiting cGAS/STING pathway activation

*Xinyu Liu1,2, Qingyang Zhou1, Yanfei Hou3, Hao Tang1, Bo Lu1, Jin Liu1, Minjiang Chen4, Yan Xu4, Mengzhao Wang4, Jingnan Li1, Bei Tan1 (1. Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China., 2. Eight-year Medical Doctor Program, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China., 3. State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China., 4. Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China.)
Comment()
4:06 PM - 4:12 PM JST(7:06 AM - 7:12 AM UTC)

[O16-07]TIMP1-Driven Macrophage Lactylation via cGAS-STING Activation Enhances Glycolysis and Senescence-Mediated Inflammation in Ulcerative Colitis

*Junbo Xiao1, Jun Yi1, Xiaowei Liu1 (1. Department of Gastroenterology, Xiangya Hospital, Central South University)
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4:12 PM - 4:18 PM JST(7:12 AM - 7:18 AM UTC)

[O16-08]HDAC3 Exacerbates Intestinal Barrier Injury in Ulcerative Colitis by Inducing mtDNA Leakage and Activating the cGAS/STING Pathway

*YUAN XIA1, Chang Liang1, YAN ZHANG1 (1. Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University)
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4:18 PM - 4:24 PM JST(7:18 AM - 7:24 AM UTC)

[O16-09]METTL3 potentiates aged CD4+T cell response and accelerates elderly ulcerative colitis via programming effector differentiation

*Yang Zhang1,2, Jun Xu1,2, Shan Cao1,2, Yiken Lin1,2, Yulan Liu1,2 (1. Department of Gastroenterology, Peking University People’s Hospital, 2. Clinical Center of Immune-Mediated Digestive Diseases, Peking University People’s Hospital)
Comment()
4:24 PM - 4:30 PM JST(7:24 AM - 7:30 AM UTC)

[O16-10]Inhibiting METTL3 in macrophages alleviates colitis by enhancing M2 polarization via upregulating IRAK-M

*Yang Zhang1,2, Jun Xu1,2, Yiken Lin1,2, Yulan Liu1,2 (1. Department of Gastroenterology, Peking University People’s Hospital, 2. Clinical Center of Immune-Mediated Digestive Diseases, Peking University People’s Hospital)
Comment()
4:30 PM - 4:36 PM JST(7:30 AM - 7:36 AM UTC)

[O16-11]The role of mesenteric inflammation-associated fibroblasts in the development of Crohn’s disease

*Jihye Park1, Yang Hee Joo2, Eun Mi Song2, Yehyun Park2, Gyoung Tae Noh3, Euno Choi4, Jieun Byun5, Ju Ran Byun2, Ho Seung Kim3, Young-Ho Ahn1, Sung-Ae Jung2 (1. Department of Molecular Medicine and Inflammation-Cancer Microenvironment Research Center, College of Medicine, Ewha Womans University, 2. Department of Internal Medicine and Inflammatory Bowel Disease Center, Ewha Womans University College of Medicine, 3. Department of Surgery, Ewha Womans University College of Medicine, 4. Department of Pathology, Ewha Womans University College of Medicine, 5. Department of Radiology, Ewha Womans University College of Medicine)
Comment()
4:36 PM - 4:42 PM JST(7:36 AM - 7:42 AM UTC)

[O16-12]SINGLE-NUCLEUS SEQUENCING REVEALS THE HETEROGENEITY OF ADIPOCYTES IN CREEPING FAT OF CROHN’S DISEASE

*Weidong Huang1, Fangting Wu1, Xiaomin Wu1, Jinshen He1, Jiaxin Wang2, Jinyu Tan1, Shanshan Xiong1, Fengfei Wu3, Xiaolei Wang4, Zhenhua Luo1, Yao Zhang2, Ren Mao1 (1. The First Affiliated Hospital of Sun Yat-sen University, 2. Ruijin Hospital, School Of Medicine, Shanghai Jiaotong University, 3. Nanfang Hospital of Southern Medical University, 4. Shanghai Tenth People's Hospital, School of Medicine, Tongji University)
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4:42 PM - 4:48 PM JST(7:42 AM - 7:48 AM UTC)

[O16-13]Optimizing the Creeping Fat Animal Model of Crohn's Disease Through Repeated Biopsy Combined with DSS Stimulation

*Fangting Wu1, Xiaomin Wu1, Jinyu Tan1, Weidong Huang1, Jie Li1, Shanshan Xiong1, Ren Mao1 (1. Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.)
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