[3A-03] Induction of Programmed Cell Death in Cancer Cells by Cyclometalated Iridium(III) Complex-Peptide Hybrids and its Mechanistic Study | The 15th Symposium on Biorelevant Chemistry

The 15th Symposium on Biorelevant Chemistry

Sep 8 - Sep 10, 2021Held Online

Back

The 15th Symposium on Biorelevant Chemistry

Sep 8 - Sep 10, 2021Held Online

[3A-03]Induction of Programmed Cell Death in Cancer Cells by Cyclometalated Iridium(III) Complex-Peptide Hybrids and its Mechanistic Study

*Kenta Yokoi¹, Chandrasekar Balachandran^1,2, Jebiti Haribabu¹, Arisa Koyamada¹, Masakazu Umezawa³, Koji Tsuchiya³, Shin Aoki^1,2,3(1. Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2. Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, 3. Research Institute for Science and Technology (RIST), Tokyo University of Science)

Download PDF

Keywords:

Programmed cell death,Iridium complex,Paratosis,Calcium,Luminescence

抗がん剤の開発では様々なPCDを誘起する薬剤の開発が求められる。我々は、カチオン性ペプチドで修飾したイリジウム（Ir(III)）錯体（Ir complex-peptide hybrid (IPH))が、paraptosisを誘導することを報告した。小胞体からミトコンドリアへの直接Ca^{2 +}輸送を誘起してミトコンドリア内Ca^{2 +}濃度の上昇と細胞内器官の空胞化を誘起することがわかったので報告する。

Back