Presentation Information
[P201]Development of activity-based fluorescent probes for tissue-clearing-based imaging
*Bo Yi1, Daichi Sakamoto1, Iori Tamura1, Yutaro Saito1, Naoki Yamada1, Shimpei Kubota2, Kazuki Tainaka3, Shinsuke Sando1 (1. Graduate School of Engineering, The University of Tokyo, 2. Institute for Genetic Medicine, Hokkaido University, 3. Brain Research Institute, Niigata University)
Keywords:
Fluorescent probe,3D imaging,Tissue clearing,Enzymatic activity
Enzymes are pivotal components of most physiological processes and are consequently involved in various pathologies. Therefore, high-resolution mapping of enzyme activities in three-dimensional space is a powerful tool for elucidating the causes of a range of diseases.
The goal of this work is the rational design of activity-based fluorescence probes compatible with tissue clearing aiming for high-resolution 3D mapping of enzymatic activity.
The goal of this work is the rational design of activity-based fluorescence probes compatible with tissue clearing aiming for high-resolution 3D mapping of enzymatic activity.