The 17th Symposium on Biorelevant Chemistry
Sep 8 - Sep 10, 2023Tokyo University of Science
The 17th Symposium on Biorelevant Chemistry
Sep 8 - Sep 10, 2023Tokyo University of Science
[1OC-08]Small-Molecule Aptamer for Regulating RNA Functions in Mammalian Cells and Animals
*Keisuke Fukunaga1,2, Dhamodharan V1, Nao Miyahira1, Yoko Nomura1, Kamila Mustafina1,3, Yasuaki Oosumi4, Kosuke Takayama4, Akira Kanai4, Yohei Yokobayashi1(1. Nucleic Acid Chemistry and Engineering Unit, OIST, 2. ELSI, Tokyo Tech, 3. Department of Biological Engineering, MIT, 4. Applied Research & Operations, Astellas Pharma Inc.)
Keywords:
RNA Aptamer,Aptazyme,Riboswitch,Gene Expression Regulation,Synthetic Biology
低分子化合物ASP2905／ASP7967に結合する新規RNAアプタマーの取得に成功した。また、動物細胞や生体内において遺伝子発現制御を可能にするリボスイッチを開発することにも成功した。