核酸関連

11:00 AM - 11:20 AM JST(2:00 AM - 2:20 AM UTC)

[3OB-05] Reducing Toxicity in Gapmer Antisense Oligonucleotides Using Acyclic Nucleic Acid Substitution.

*Jumpei Ariyoshi¹, Masaya Higuchi², Ayano Otsuka¹, Mioka Okuno¹, Nozomi Tanigawa¹, Ayaka Minamikawa¹, Manaka Yamaoka¹, Hiroyuki Oyama¹, Hiroyuki Asanuma², Yukiko Kamiya^1,2 (1. Kobe Pharmaceutical University, 2. Graduate School of Engineering, Nagoya University)

Keywords:

oligonucleotide therapeutics,Gapmer,Antisense oligonucleotides,artificial nucleic acid