Peptides

10:50 AM - 11:10 AM JST(1:50 AM - 2:10 AM UTC)

[2OA-05] Comprehensive analysis of the impact of backbone N-methylation pattern of Cyclosporin A on the passive membrane permeability

*Jumpei Morimoto¹, Motoki Sugano¹, Yuto Hirota¹, Mao Yamaguchi¹, Koji Umezawa², Takumi Ueda^3,4, Koh Takeuchi⁴, Shinsuke Sando¹ (1. Graduate School of Engineering, The University of Tokyo, 2. Graduate School of Science and Technology, Shinshu University, 3. Graduate School of Pharmaceutical Sciences, The University of Osaka, 4. Graduate School of Pharmaceutical Sciences, The University of Tokyo)

Keywords:

Cyclic peptides,Passive membrane permeability,Cyclosporin A,Structural chameleonicity