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Development of gene therapy for vision restoration by using a channelrhodopsin with high light sensitivity

共催:JST/CREST 「オプトバイオ」

Rhodopsin is a general term for photoreceptive proteins which bind retinal as a chromophore.  Rhodopsins are classically classified into two types, animal-type and microbial-type.  These two types show no sequence similarities with each other, which leads to the diversity of their molecular functions.  However, recent accumulation of the molecular properties of rhodopsins has crossed the border between animal-type and microbial-type.  Moreover, the application of various rhodopsins to optogenetics not only contributes to the understanding of the molecular mechanisms underlying the physiological functions in animals but also opens a new field in the treatments of diseases.  In this symposium, we would like to introduce the “borderless” rhodopsin world.

Biophysical Society of Japan

The 61st Annual Meeting of the Biophysical Society of Japan

The 61st Annual Meeting of the Biophysical Society of Japan

[1SDA-6]Development of gene therapy for vision restoration by using a channelrhodopsin with high light sensitivity