Presentation Information
[450101-01-01]Revealing respiratory physiology defence of inhaled airborne particles through multiphase flow simulations
Prof. Kiao Inthavong (RMIT University)
The respiratory system is a remarkable structure with complex physiological functions that sustain life autonomously by delivering oxygen to the body and expelling carbon dioxide. On average, a person takes about 20,000 to 25,000 breaths per day, equating to approximately 10,000 to 12,500 liters of air. Hidden within this system are evolutionary anatomical features that serve as defense mechanisms, protecting us from airborne pollutants and viruses. Recent advancements in radiology have enabled multiphase flow simulations within computational fluid dynamics (CFD) for respiratory models. In this talk, I will present recent simulation outcomes that reveal the intricate and evolutionary adaptations of the airways that serve to protect us. This includes an analysis of the risks associated with exposure to airborne pollutants such as pollen, silica, asbestos, and viruses (e.g., COVID-19). Furthermore, I will explain how certain sub-anatomies serve extended, hidden functions in addition to their traditional roles—for instance, the larynx does more than just enable vocalization. The talk will also explore how the airway's shape can be leveraged to enhance drug delivery, offering new strategies to combat systemic diseases. Finally, the talk will conclude with future work that aims to enable instant diagnosis directly from a visit to the radiology center.