[2S06m] 15. Advanced Cell and Cell Culture Engineering for Biopharmaceuticals and Functional Food - Part 4

10:00 AM - 10:30 AM JST(1:00 AM - 1:30 AM UTC)

[2ACCE-02] Exosomes: The Molecular Link Between Functional Foods and Multi-Organ Health

○Yoshinori Katakura¹ (1. Kyushu Univ. (Japan))

Keywords:

exosome,anti-aging,inter-organ interaction

Our previous studies highlight the critical role of exosome-mediated intercellular and inter-organ communication triggered by functional food components and probiotics. We demonstrate that specific dietary factors exert systemic health benefits by inducing the secretion of functional exosomes from various tissues. Concerning the gut-brain axis, components such as carnosine, γ-aminobutyric acid (GABA), and Urolithin A activate intestinal epithelial cells to secrete exosomes containing specific microRNAs. These exosomes promote neurite outgrowth and mitochondrial activation in neuronal cells. In aged mouse models, oral administration of GABA and Urolithin A ameliorated cognitive decline and suppressed hippocampal neuroinflammation via circulating exosomes.Furthermore, the gut-muscle and muscle-brain axes are also regulated by these mechanisms. For instance, Fructobacillus fructosus OS-1010 stimulates intestinal cells to release exosomes that enhance mitochondrial function and differentiation in muscle cells. Similarly, carnosine acts directly on muscle cells, inducing the secretion of myokines and exosomes that further promote neuronal activation.Beyond internal organs, exosome-mediated interactions regulate skin and hair regeneration. The polyphenol fisetin activates keratinocytes, triggering the release of exosomes that stimulate hair follicle stem cell proliferation and mitochondrial activity, ultimately promoting hair growth.In conclusion, functional ingredients exert their neuroprotective, myogenic, and regenerative effects by modulating exosomal microRNA cargo. This exosome-mediated network represents a novel molecular basis for how dietary interventions systematically regulate physiological functions and counteract age-related decline.