[3S04a] 11. The Society for Biotechnology - Part 2

2:00 PM - 2:25 PM JST(5:00 AM - 5:25 AM UTC)

[3SBT-08-KL] Powering Biomanufacturing with Lab-Generated Data-Driven Engineering Biology

○Tomohisa Hasunuma¹ (1. Kobe University (Japan))

Keywords:

Metabolic Engineering,Microorganism,Enzyme,Lab automation,Computational Analysis

The basic concept of engineering biology is the design and construction of biological systems with novel functions, which will lead to a better understanding of the mechanisms of life, but also the realization of valuable industrial applications in fields such as chemistry, energy, medicine, and food. Our research group is developing novel capabilities in the theme of bioengineered cells and systems, applying metabolic engineering of microbes for high-value chemical production, as there is a great deal of industrial interest in biomanufacturing using microorganisms. Recent advances in genome synthesis and engineering, high-throughput technologies, measurement technologies, and computational science have enabled the faster and more reliable implementation of increasingly ambitious design strategies. We launched a bio-foundry approach for rapid engineering of model microorganisms, and we have succeeded in developing Escherichia coli and yeast strains that can produce high amounts of useful molecules. Kobe University Engineering Biology Research Center (EGBRC) is working on the development of "Smart Cells," a microbial strain that can produce high amounts of useful substances using computer-designed metabolic pathways and enzymes. In particular, what determines the quality of the design is the experimental data and the analysis and evaluation technology that generates it. Thus, we are developing high-throughput screening technology using supercritical fluids and metabolomics that achieves high reproducibility by automating the pretreatment process. In addition, we have also developed a DBTL platform for enzyme engineering. In this session, I would like to introduce our "Smart Cell Development Platform" incorporating the elemental technologies we developed and look into the future of bioengineering.