[3S04a] 11. The Society for Biotechnology - Part 2

2:25 PM - 2:50 PM JST(5:25 AM - 5:50 AM UTC)

[3SBT-09] Efficient biorefinery of renewable biomass for sustainable bioproduction using microbial cell factories

○Xinqing Zhao¹ (1. Shanghai Jiao Tong University (China))

Keywords:

Industrial microbial strains,Fermentation optimization,Renewable biomass,Stress tolerance,Genome mining

[Purpose] To efficiently use the fermentable sugars from renewable biomass for bioproduction and sustainable development.

[Method] Microbial strains were isolated, designed, engineered and used as cell factories to produce biofuels and biochemicals using glucose and xylose in the biomass hydrolysate.

[Results] Both natural and industrial yeast strains and Trichoderma strains were optimized to produce fuel ethanol, succinic acid, antioxidants and cellulase. Stress tolerance of yeast under industrial conditions was optimized based on multiomics analysis, and regulators for cellulase production were identified.

[Consideration] Natural strains and industrial strains are valuable sources for bioproduction. Chromatin level regulation contributes to metabolic regulation and stress tolerance. Genome mining provides novel insights and targets for engineering microbial metabolism.

[Conclusion] Microbial cell factories have great potential to be optimized for efficient bioproduction using renewable sugars.