Presentation Information
[P02-155]Reprogramming and Optimization of Industrial Microbial Chasses for Commercial Applications
○Shihui YANG1 (1. Hubei University (China))
Keywords:
Non-model microorganism,Chassis cells,Synthetic biology,Genome editing,Inhibitor tolerance,Platform biochemicals
Abstract:
Biomanufacturing contributes to environmental protection, carbon neutrality, as well as food and energy security. The design, reprogramming, construction, and optimization of high-yield, robust industrial strains are central to biomanufacturing. Although systems and synthetic biology have advanced our understanding of chassis cells and enabled the construction of microbial cell factories, the development of high-yield, robust industrial strains still faces many challenges. Using the unique facultative anaerobic ethanologenic bacterium Zymomonas mobilis as an example, this talk will discuss the challenges and solutions associated with the reprogramming and optimization of high-yield, robust industrial strains for commercial applications, which includes the establishment of a dedicated database of genetic information and biological parts, development of efficient genome-editing toolkits required for reprogramming and optimization, and engineering strategies to convert the natural ethanologenic strain into a platform chassis for constructing microbial cell factories that produce platform biochemicals for the synthesis of biofuels and biomaterials.
Biomanufacturing contributes to environmental protection, carbon neutrality, as well as food and energy security. The design, reprogramming, construction, and optimization of high-yield, robust industrial strains are central to biomanufacturing. Although systems and synthetic biology have advanced our understanding of chassis cells and enabled the construction of microbial cell factories, the development of high-yield, robust industrial strains still faces many challenges. Using the unique facultative anaerobic ethanologenic bacterium Zymomonas mobilis as an example, this talk will discuss the challenges and solutions associated with the reprogramming and optimization of high-yield, robust industrial strains for commercial applications, which includes the establishment of a dedicated database of genetic information and biological parts, development of efficient genome-editing toolkits required for reprogramming and optimization, and engineering strategies to convert the natural ethanologenic strain into a platform chassis for constructing microbial cell factories that produce platform biochemicals for the synthesis of biofuels and biomaterials.
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