[P001] Poster

12:10 PM - 1:00 PM JST(3:10 AM - 4:00 AM UTC)

[P01-061] Biosynthesis of streptothricin-related compounds.

○Chitose Maruyama¹ (1. Fukui Prefectural University (Japan))

Keywords:

antibiotics,biosynthesis,Streptomyces

Streptothricin, ST, is a classic antibiotic found by Dr. Waksman in 1943. The chemical structure is characterized by a streptothrisamine core structure with one L-β-lysine (β-Lys) residue. Since his finding, many analog compounds possessing a β-Lys oligomeric chain (2 to 7 β-Lys residues) have been isolated from Streptomyces strains. In addition to these ST compounds (STs), Streptomyces strains have been known to produce ST-related compounds, which possess a glycine-derived side chain instead of the β-Lys residue. Interestingly, they exhibit some characteristic biological activities by further biosynthetic diversifications with methylation, formimidoylation, and/or peptidylation. However, these ST-related compounds, like STs, showed toxicities against both eucaryotes and procaryotes. Therefore, understanding their biosynthesis allows us to generate new ST-related compounds specific to multidrug-resistant pathogens. In this presentation, we will share with you the enzymes identified in our biosynthetic studies that would be useful for combinatorial biosynthesis.