Presentation Information
[P03-330]Keratin-Marine Adhesive Protein Nanocomposites with Enhanced Adhesive Strength
○Yang Wei1 (1. National Taipei University of Technology/ Chemical Engineering and Biotechnology Department (Taiwan))
Keywords:
mussel foot proteins,keratin intermediate filaments,nanoparticles,adhesive strength,spray drying
[Purpose] Keratin intermediate filaments (KIFs) are natural proteins with good biocompatibility, but their inherently low adhesion in moist environments limits their clinical potential. To address this, this study enhances keratin's wet adhesion by incorporating mussel foot proteins (MFPs), renowned for their underwater adhesive capabilities.
[Method] KIFs extracted from human hair were blended with MFPs at various ratios and fabricated into nanoparticles via spray drying. The resulting particles were analyzed for size and morphology, and their adhesive performance was evaluated.
[Results] Results showed that incorporating MFPs increased nanoparticle size, suggesting strong intermolecular interactions. In adhesion tests, pure keratin nanoparticles exhibited an initial adhesion strength of 0.89±0.05 kPa. The addition of MFPs significantly enhanced this short-term adhesion to 2.93±0.19 kPa, a more than three-fold improvement.
[Conclusion] In summary, functionalizing keratin with MFPs and processing them into nanoparticles via spray drying is an effective strategy to improve adhesion under moist conditions, demonstrating great potential for applications in wet dressings and tissue adhesive materials.
[Method] KIFs extracted from human hair were blended with MFPs at various ratios and fabricated into nanoparticles via spray drying. The resulting particles were analyzed for size and morphology, and their adhesive performance was evaluated.
[Results] Results showed that incorporating MFPs increased nanoparticle size, suggesting strong intermolecular interactions. In adhesion tests, pure keratin nanoparticles exhibited an initial adhesion strength of 0.89±0.05 kPa. The addition of MFPs significantly enhanced this short-term adhesion to 2.93±0.19 kPa, a more than three-fold improvement.
[Conclusion] In summary, functionalizing keratin with MFPs and processing them into nanoparticles via spray drying is an effective strategy to improve adhesion under moist conditions, demonstrating great potential for applications in wet dressings and tissue adhesive materials.
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