[P006] Poster

1:00 PM - 1:50 PM JST(4:00 AM - 4:50 AM UTC)

[P03-340] Synergistic Polyvinyl Alcohol/Sodium Alginate Composite Nanofibers: Optimizing the Sustained Release of 5-Fluorouracil

○Yu-Cheng Chang¹, Chen-Yu Wu¹ (1. Feng Chia University (Taiwan))

Keywords:

drug delivery,polyvinyl alcohol,sodium alginate,nanofibers,5-fluorouracil

The increasing incidence of early-onset cancer and the rapid metabolism of chemotherapeutic agents, which often results in burst release and reduced drug utilization efficiency, highlight the urgent need for sustained drug delivery systems. In this study, drug-loaded nanofibrous mats were fabricated via a simple and cost-effective electrospinning technique using polyvinyl alcohol (PVA) and sodium alginate as polymer matrices. The effects of polymer concentration and composition on fiber morphology and drug release behavior were systematically investigated. Scanning electron microscopy revealed that nanofibers prepared with 7 wt% PVA exhibited uniform, well-defined fibrous structures, whereas increasing the sodium alginate content produced denser fiber networks. X-ray diffraction analysis indicated that the nanofibers were amorphous. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed the successful incorporation of sodium alginate, PVA, and 5-fluorouracil (5-FU) within the nanofibrous matrix without compromising drug integrity. Drug release studies demonstrated that higher sodium alginate content effectively reduced the initial burst release, with 0.75 wt% sodium alginate yielding the optimal release profile. The nanofibers exhibited favorable 5-FU release under acidic and neutral conditions, whereas accelerated release was observed in alkaline environments, likely due to drug instability. Notably, the optimal release behavior corresponds well with the physiological pH range of the gastrointestinal tract, where 5-FU is clinically applied. Furthermore, ciprofloxacin release tests confirmed the versatility of the developed system for antibiotic delivery. These results demonstrate that the electrospun PVA/sodium alginate nanofibers represent a promising platform for controlled drug delivery applications.