Presentation Information
[P04-574]Anti-melanogenic effects of small extracellular vesicles derived from Haematococcus lacustris green-stage culture medium
○yesol Kim1, Wook-Chul Kim1, Yun-Su Lee1, Seo-Rin Jung1, Seung-Hong Lee1 (1. Department of Medical Science, Soonchunhyang University, Asan, Republic of Korea (Korea))
Keywords:
Haematococcus lacustris,culture media,extracelluar vesicles,anti-melanogenic,zebrafish
[Purpose]
Microalgae are gaining attention as sustainable bioresources for cosmetic and biomedical applications due to their rich repertoire of functional compounds. Although previous studies have mainly focused on intracellular metabolites, the culture medium itself may also contain biologically active extracellular substances. This study aimed to investigate the extracellular vesicles (EVs) present in the culture medium of green-stage Haematococcus lacustris and to assess their anti-melanogenic potential. [Method]
Extracellular vesicles were isolated and purified from the culture medium of green-stage H. lacustris. Their biological activity was then evaluated in a zebrafish model to determine their effect on melanin production and potential toxicity.
[Results]
The purified EVs significantly reduced melanin synthesis in zebrafish without causing detectable toxicity. These results indicate that EVs derived from the culture medium possess notable anti-melanogenic activity.
[Consideration]
While H. lacustris has been extensively studied for astaxanthin accumulation under stress conditions, the biological properties of its green-stage culture medium have remained largely uncharacterized. The present findings suggest that extracellular vesicles may constitute an important bioactive component of the medium and could contribute to its functional value. [Conclusion]
This study demonstrates that extracellular vesicles isolated from the culture medium of green-stage H. lacustris exhibit promising anti-melanogenic effects. These findings support the potential of green-stage H. lacustris as a sustainable microalgal platform for the development of cosmetic ingredients.
Microalgae are gaining attention as sustainable bioresources for cosmetic and biomedical applications due to their rich repertoire of functional compounds. Although previous studies have mainly focused on intracellular metabolites, the culture medium itself may also contain biologically active extracellular substances. This study aimed to investigate the extracellular vesicles (EVs) present in the culture medium of green-stage Haematococcus lacustris and to assess their anti-melanogenic potential. [Method]
Extracellular vesicles were isolated and purified from the culture medium of green-stage H. lacustris. Their biological activity was then evaluated in a zebrafish model to determine their effect on melanin production and potential toxicity.
[Results]
The purified EVs significantly reduced melanin synthesis in zebrafish without causing detectable toxicity. These results indicate that EVs derived from the culture medium possess notable anti-melanogenic activity.
[Consideration]
While H. lacustris has been extensively studied for astaxanthin accumulation under stress conditions, the biological properties of its green-stage culture medium have remained largely uncharacterized. The present findings suggest that extracellular vesicles may constitute an important bioactive component of the medium and could contribute to its functional value. [Conclusion]
This study demonstrates that extracellular vesicles isolated from the culture medium of green-stage H. lacustris exhibit promising anti-melanogenic effects. These findings support the potential of green-stage H. lacustris as a sustainable microalgal platform for the development of cosmetic ingredients.
Comment
To browse or post comments, you must log in.Log in