[4S00m] 01. ASBA - Part 10

10:10 AM - 10:30 AM JST(1:10 AM - 1:30 AM UTC)

[4ASBA-02-KL] Engineering Microbes for Dynamic Host-Microbiome Modulation

○Matthew Chang (1. National University of Singapore (Singapore))

Keywords:

Synthetic Biology,Microbiome

Recent advances in understanding the composition and function of the human microbiota have highlighted its critical roles in health and disease, spurring the development of targeted interventions. At the same time, synthetic biology has enabled the creation of programmable genetic circuits and the reprogramming of living cells, paving the way for next-generation microbiota-based therapies. In this presentation, I will share our latest progress in transforming commensal microbes into multifunctional platforms with clinically relevant capabilities. In particular, I will highlight efforts to develop these microbes as autonomous therapeutic agents that operate in vivo to modulate the microbiome and target infections, metabolic disorders, and cancers. Our research establishes a strong foundation for rewiring host-microbiome interactions and underscores the promise of microbial engineering as a new class of clinical