International Conference on Cytochrome P450

[Opening]

[Closing]

[Poster Set up]

[Session 1-1]microRNAs regulating P450 expression and activities: perspective for future medicine

^○Miki Nakajima (Drug Metabolism and Toxicology, Kanazawa University)

[Welcome reception]

[Session 1-2]Regulation and Functions of Steroid Hydroxylase P450scc (CYP11A1)

^○Bon-chu Chung (Institute of Molecular Biology, Academia Sinica)

[Session 1-3]Regulation of hepatic cytochrome P450 expression by Wnt/β-catenin signaling

^○Albert Braeuning ^1,2(1.Institute of Experimental and clinical Pharmacology and Toxicology, Department of Toxicology, University of Tuebingen, 2.Food Safety, Federal Institute for Risk Assessment)

[Poster award＆Conference Diner]

[Session 1-4]Regulation of CYP3A gene expression by sterol-responsive transcription factors

^○Kouichi Yoshinari (School of Pharmaceutical Sciences, University of Shizuoka)

[Session 2-1]Models for Active Oxygen Intermediates of Copper Monooxygenases

^○Shinobu Itoh (Graduate School of Engineering, Osaka University)

[Session 2-2]Particulate methane monooxygenase

^○Amy C. Rosenzweig (Departments of Molecular Biosciences and of Chemistry, Northwestern University)

[Session 2-3]Highly reactive anti-dioxo high-spin diiron(IV)

^○Masahito Kodera (Department of Molecular Chemistry and Biochemistry, Doshisha University)

[Session 2-4]TRYPTOPHAN DIOXYGENATION BY HEME-BASED DIOXYGENASES: FROM STRUCTURE TO FUNCTION

^○Syun-Ru Yeh (Physiology and Biophysics, Albert Einstein College of Medicine)

[Session 3-1]BIOLOGY OF NUCLEAR RECEPTORS CAR AND PXR AS CELL SIGNAL TRANSDUCING SCAFFOLDS

^○Masahiko Negishi , Saki Gotoh (Reproductive Developmental Biology Laboratory, National Institute of Enviromental Health Sciences, NIH)

[Session 3-2]CYP7A1 and bile acid signalling in hepatic lipid metabolism and disease

^○John Y. L. Chiang (Integrative Medical Sciences, Northeast Ohio Medical University)

[Session 3-3]Signaling Pathways Regulating Steroid Hydroxylase Gene Transcription

^○Marion B. Sewer (School of Pharmacy, University of California San Diego)

[Session 3-4]Nuclear receptor and metabolism

^○Takashi Baba , Ken-ichirou Morohashi (Molecular Biology, Kyushu University)

[Session 4-1]Structure, Function, and Inhibition of Steroidogenic Human Cytochrome P450 17A1

^○Emily E. Scott (Department of Medicinal Chemistry, University of Kansas)

[Session 4-2]Crystal structure of CYP90B1, which is involved in brassinosteroid biosynthesis

^○Shingo Nagano ¹, Masahiro Kanadani ¹, Tomoya Hino ¹, Masaharu Mizutani ²(1.Department of Chemistry and Biotechnology, Tottori University, 3.Graduate School of Agricultural Science, Kobe University)

[Session 4-3]Structural Plasticity of Human, Rabbit, and Rodent CYP2B Enzymes: Role in Species Differences

^○James Robert Halpert (School of Pharmacy, University of Connecticut)

[Session 4-4]Structure-Aided Drug Discovery Targeting CYP51

^○Larissa M. Podust ¹, Jair Lage Siqueira-Neto ¹, James H. McKerrow ¹, Ruben Abagyan ¹, Jun Yong Choi ², William R. Roush ², Claudia M. Calvet ³(1.Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, 3.Department of Chemistry, Scripps Florida, 5.Cellular Ultra-Structure Laboratory, Oswaldo Cruz Institute (IOC), FIOCRUZ)

[Session 5-1]Quantitative Prediction of Hepatic Disposition of Drugs and Metabolites by In Vitro Sandwich-cultured Hepatocytes and by In Vivo Biomarker

^○Ikumi Tamai (Faculty of Pharmaceutical Sciences, Institute of Medical Pharmaceutical and Health Sciences Kanazawa University)

[Session 5-2]P450-Transporter Interplay

^○Richard B. Kim (Medicine, Western University)

[Session 5-3]Methods for testing contributions of drug metabolizing enzymes and transporters to the pharmacokinetic profile of a drug

^○Ichiro Ieiri (Clinical Pharmacokinetics, Kyushu University)

[Session 5-4]Creating "Realistic" Virtual Patients for Purpose of Drug Development: The Importance of Inter-Correlations between Enzyme and Transpoter Abundances

^○Amin Rostami-Hodjegan (Faculty of Medical and Human Sciences, University of Manchester & Certara)

[Session 6-1]Peering into the exaptations of ohnologous cytochromes P450

^○C. S. Raman (University of Maryland)

[Session 6-2]The nature of ferryl heme

^○Emma L. Raven (Chemistry, University of Leicester)

[Session 6-3]The Role of Redox Partner Binding in P450 Conformational Dynamics

Sarvind Tripathi , Huiying Li , Scott Hollingsworth , Dipanwita Batabyal ,^○Thomas Poulos (Departments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine)

[Session 6-4]Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation Chemistry

^○Wonwoo Nam (Department of Chemistry, Ewha Womans University)

[Session 7-1]Mitigating Idiosyncratic Toxicity Risks with the N1-substituted-6-arylthiouracils Class of Myeloperoxidase Inactivators: Identification of a Clinical Candidate to Treat Cardiovascular Diseases

^○Amit Kalgutkar (Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Inc.)

[Session 7-2]CYTOCHROME 450 ENZYMES IN THE HUNT FOR ACTIVE METABOLITES

^○R. Scott Obach (Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer Inc.)

[Session 7-3]Utility of iPS Cells for Study of Drug Metabolism and Pharmacokinetics: Differentiation of human iPS cells into hepatocytes and enterocytes

^○Tamihide Matsunaga (Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University)

[Session 7-4]The use of xenobiotic receptor and P450 humanized mice in elucidating the mechanisms of drug-induced toxicity

^○Frank J. Gonzalez ¹, Jie Cheng ¹, Xiaochao Ma ¹(1.Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, 3.Department of Pharmaceutical Sciences, University of Pittsburgh)

[Session 8-1]Cytochrome P450 Oxidations: A Controlled Burn of Inert Organic Compounds

^○Michael T. Green (Chemistry, Penn State University)

[Session 8-2]In search of Compound I of cytochrome P450

^○Willem H. Koppenol , Huriye Erdogan , An Vandemeulebroucke , Thomas Nauser , Patricia L. Bounds (Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH))

[Session 8-3]Aromatic Peroxygenases: Novel Heme-thiolate P450 Analogs

^○John T. Groves , Xiaoshi Wang , Christin B. Monroe , Nicholas C. Boaz (Department of Chemistry, Princeton University)

[Session 8-4]Ligand-Dependent Conformational Dynamics of CYP119 by Two-Dimensional NMR and X-Ray Crystallography

^○Paul R. Ortiz de Montellano ¹, Debashree Badsuhar ¹, Yarrow Madrona ¹, Clinton R. Nishida ¹, Sylvie Kandel ², Jed N. Lampe ³(1.Pharmaceutical Chemistry, University of California San Francisco, 3.XenoTech, XenoTech LLC, 5.Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center)

[Session 9-1]How do reactive metabolites lead to the immune response that can lead to an idiosyncratic drug reaction?

^○Jack Uetrecht (Pharmaceutical Sciences, University of Toronto)

[Session 9-2]The role of drug and drug metabolite-specific T-cells in immunological drugs reactions targeting liver and skin

^○Dean J. Naisbitt (MRC Centre for Drug Safety Science, the Department of Molecular and Clinical Pharmacology, The University of Liverpool)

[Session 9-3]Integrating metabolic bioactivation alongside other adverse properties to predict and avoid human adverse drug reactions

^○Gerry Kenna (FRAME Office, FRAME)

[Session 9-4]Risk Assessment of Chemically Reactive Metabolites and Idiosyncratic Drug Toxicity in Drug Discovery and Development

^○Hideo Takakusa (Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd)

[Session 10]Introduction of the session

^○Yuri Aoyama (Department Bioinformatics, Faculty of Engineering, Soka University)

[Session 10-1]Liver steroid-metabolizing P450s: Sex and hormone-dependent genomic and epigenetic regulatory mechanisms

^○David J. Waxman , Dana Corona Lau , Gracia M. Bonilla , Tisha Melia , Pengying Hao (Department of Biology and Bioinformatics Program, Boston University)

[Session 10-2]De novo synthesis and conversion of neuroprotective steroids by brain P450

^○Takeshi Yamazaki , Yasuhiro Ishihara (Graduate School of Integrated Arts and Sciences, Hiroshima University)

[Session 10-3]Rapid dual regulation of cyp19A1 (P450arom) in nerve cells as neuroestrogen synthase

^○Nobuhiro Harada ¹, Shin-ichiro Honda ², Takanori Hayashi ¹(1.Department of Biochemistry, Fujita Health University School of Medicine, 3.Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University)

[Session 10-4]The Molecular Mechanisms of Cytochrome P450: What's Next?

^○Stephen G. Sligar (School of Molecular and Cellular Biology, University of Illinois)

[Session 11-1]Use of modeling and simulation for the prediction of drug interactions

^○Kiyomi Ito (Research Institute of Pharmaceutical Sciences, Musashino University)

[Session 11-2]Japanese final draft guideline on drug interaction studies for drug development and labeling recommendations

^○Yoshiro Saito (Medicinal Safety Science, National Institute of Health Sciences)

[Session 11-3]A Scientific Perspective on Drug Interaction Evaluation in Drug Development

^○Lei Zhang (USA)

[Session 11-4]The practical aspects of complying with regulatory guidelines on drug interactions: Some notable strengths and weaknesses of in vitro testing

^○Andrew Parkinson (CYP450, XPD Consulting)