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Mon. Mar 16, 2026

Tue. Mar 17, 2026

Wed. Mar 18, 2026

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Visualizing Intracellular Liquid–Liquid Phase Separation to Unlock Neurodegenerative Disease Mechanisms and Enable Drug Discovery

Research in nanobioengineering based on the visualization and dynamic control of structure-specific molecular functions is rapidly advancing toward next-generation medical and environmental applications. This symposium introduces cutting-edge studies emerging from the convergence of physics, chemistry, biology, and materials science: cell protection under freezing and low-temperature environments by ice-binding proteins, biosensing based on the extracellular electron transfer mechanisms of electroactive bacteria, disruption of intracellular liquid-liquid phase separation and its disease relevance, formation processes of protofibrils in amyloidosis-related proteins, and dynamic function design of hydrogels based on molecular-level structure-property correlations. Furthermore, discussions will explore nanoscale molecular control spanning from in vitro to in vivo, along with the identification of new molecular targets, and applications to diagnostics, therapeutics, and analytical technologies from a neuroscientific perspective. Participants will gain a comprehensive view of how dynamic molecular functions can be harnessed to create innovative biomedical and environmental solutions. (This session is co-hosted with the TRiSTAR Program: https://tristar.sec.tsukuba.ac.jp/, Strategic Professional Development Program for Young Researchers by MEXT.)

Visualizing and Manipulating Molecules: Nanobio Strategies Driven by Dynamic Regulation of Molecular Functions for Medical and Environmental Applications

The 99th Annual Meeting of the Japanese Pharmacological Society

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[3-SS3-04]Visualizing Intracellular Liquid–Liquid Phase Separation to Unlock Neurodegenerative Disease Mechanisms and Enable Drug Discovery

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