The 99th Annual Meeting of the Japanese Pharmacological Society

Chair:Hiroshi Hibino(Div. of Glocal Pharmacol., Dept. of Pharmacol, Grad. Sch. of Med., Osaka Univ.)

This lecture presents an interdisciplinary approach that applies synchrotron radiation X-ray analysis, a cornerstone of material science, to medicine and pharmacy for the precise visualization of trace element dynamics in biological tissues. Using synchrotron radiation X-ray fluorescence analysis, we have successfully observed the distribution of platinum-based anti-cancer agents within human colorectal cancer tissues. Our findings demonstrate that drug localization is closely correlated with heterogeneous tissue structures and the behavior of essential endogenous metals. Furthermore, I will discuss the potential of chemical state analysis using X-ray absorption spectroscopy. By integrating functional information-such as bonding states and valence changes-with quantitative distribution data, we can transcend simple mapping to understand the actual state of drugs in situ. This approach aims to establish a novel measurement platform that contributes to identifying true pharmacologically active sites and elucidating the mechanisms of drug resistance. Through this presentation, I propose how high-precision analytical techniques from material science can provide a new foundation for understanding complex pharmacological phenomena at the elemental level.