[16p-C43-1~12] 1.5 Instrumentation, measurement and Metrology

1:30 PM - 1:45 PM JST(4:30 AM - 4:45 AM UTC)

[16p-C43-3] Particulate size and density distribution determination using resonant mass measurement method combined with asymmetrical flow field-flow fractionation

〇Haruhisa Kato¹, Ayako Nakamura¹ (1.AIST)

Keywords:

particle characterization,resonant mass measurement,field-flow fractionation

There is no doubt that knowing the size of nano- and micro-sized materials is crucial to control their physicochemical and functional characteristics in industrial and biotechnological fields, such as photonic, electronic, and drug delivery materials. In particular, density is one of the important characteristics of the functional application to estimate the composition, including the purity and hollow structure of the particles. Hollow-structured particles are used in the drug delivery field and the estimation of the size of the hollow area is important for the introduction of the drug materials into the particles. The density estimation of the particles is beneficial in this area since the density is strongly related to their loading capability of drug product into the hollow/mesoporous capsule. A novel characterization system using a combinational analysis of the resonant mass measurement and asymmetrical flow field-flow fractionation methods was therefore developed as a hybrid analytical tool for the particle density of mixtures of different-sized materials.