[18a-C31-1~9] 12.7 Biomedical Engineering and Biochips

9:00 AM - 9:15 AM JST(12:00 AM - 12:15 AM UTC)

[18a-C31-1] Evaluation of a boronic-acid based fluorescent hydrogel for microneedle sensors

〇Masahiro Fukuhara¹, Yukihiro Kanda^1,2, Hiroaki Takehara^1,2, Kevin Barthelmes³, Akira Matsumoto^1,3, Takanori Ichiki^1,2 (1.Tokyo Univ., 2.iCONM, 3.Tokyo Medical and Dental Univ.)

Keywords:

microneedle,optical measurement,glucose sensing

Bioresorbable polymers are useful materials for medical devices used in-body, and the development of precision processing technology aimed at miniaturizing devices is progressing. In particular, bioresorbable polymer microneedles have attracted attention as a minimally invasive transdermal drug delivery technology from a safety perspective. This study is focused on applying microneedle technology to biometrological devices. We have previously fabricated a microneedle device for optical measurements, with the tip filled with a fluorescent hydrogel, aiming to realize a fluorescence detection system at the microneedle tip. In this study, for proof of concept of the device, we evaluated the functionality of a glucose-responsive boronic acid fluorescent hydrogel that can be loaded at the needle tip.