[19a-P02-1~10] 3.3 Biomedical optics

[19a-P02-6] Effects of ethanol exposure on cardiac development in chick embryos imaged with swept source OCT

〇(B)Zuishu Betsudan¹, Rikuto Noguchi¹, Ryuichiro Yamazaki¹, Takashi Yamaoka¹, Yuuta Moriyama^1,2, Toshiyuki Mitsui¹ (1.Aogaku Univ., 2.PRESTO, JST)

Keywords:

Optical coherence tomography,Occurrence,Heart

Environmental factors, such as alcohol consumption, as causes of congenital heart diseases (CHD) in newborns are still under discussion, although they are statistically significant. We investigated the effect of ethanol exposure on chick embryos to test its impact on CHD. We continuously observed chick embryos using a shell-less culture method and swept-source optical coherence tomography (SS-OCT). SS-OCT provides 4D images of heart development. Ethanol exposure caused variations in heart rate and morphology, as well as disruptions in the smooth sequential motion of the heart.