[10p-N305-1~12] 12.7 Biomedical Engineering and Biochips

2:00 PM - 2:15 PM JST(5:00 AM - 5:15 AM UTC)

[10p-N305-3] Functional response and self-repair processes after focal injury in artificial neuronal networks with hierarchically modular structure

〇(D)Keita Watanabe^1,2, Hideaki Yamamoto^1,2,3, Takuma Sumi³, Hakuba Murota^1,2, Hironobu Osaki⁴, Kenshiro Kawamoto⁴, Teppei Matsui⁴, Yoshito Masamizu⁴, Shigeo Sato^1,2, Ayumi Hirano-Iwata^1,2,3 (1.RIEC,Tohoku Univ., 2.Grad. Sch. Eng., Tohoku Univ., 3.AIMR, Tohoku Univ., 4.Grad. Sch. Brain Sci., Doshisha Univ.)

Keywords:

microfluidic device,cultured neuronal networks,calcium imaging

In this study, we constructed an experimental system using laser microdissection that enables selective damage to specific connection sites in an artificial neuronal circuit replicating the hierarchical modular architecture observed in the mammalian cerebral cortex. Furthermore, from the perspective of structure–function relationships, we quantitatively analyzed how the location of damage affects the network’s damage tolerance and self-repair capacity, and we report the results herein.