Presentation Information
[8a-P07-8]Design and Fabrication of Self-Folding Inkjet-Printed Electrochemical Sensors for 3D Cellular Organization
〇(M2)Eduardus Ariasena1, Toshinori Fujie1 (1.School of Life Science and Technology, Institute of Science Tokyo)
Keywords:
Self-folding,Inkjet-printing,Electrochemical sensor
Micro-physiological systems (MPS) with electronic sensors offer an ethical and simplified alternative to animal testing by utilizing cell cultures. Recent studies have introduced bilayer stress-mismatch self-folding in flexible materials, enabling the fabrication of 3D-shaped devices for organizing 3D cells. This approach helps monitor 3D cellular physiology, which mimics real cellular conditions. Here, we developed thermally induced self-folding electrochemical sensors on flexible polymer films for 3D extracellular activity monitoring. Electrochemistry was chosen for its ability to detect molecules like dopamine. Inkjet printing was used to pattern gold electrodes on 5 µm Kapton films, which are then coated with polyimide (PI) ink as insulation and pre-strain promoter. PI polymerization temperature affected pre-strain levels, leading to a mismatch with the substrate and triggering self-folding ability. The sensors show potential for real-time, non-invasive monitoring of 3D cell models.