Presentation Information
[9p-S203-7]Single-molecule biomolecular detection methods for biosensors applicable in space environments
〇Yuki Komoto1 (1.Osaka Univ. SANKEN)
Keywords:
Single-molecule measurement,Break Junction
Space research has recently gained significant attention across academic and industrial sectors. Among the many emerging fields, biosensing in space is of particular interest due to its potential in understanding the origins of life and enabling future space-based medical applications. Space biosensors must meet strict requirements such as compact size, low power consumption, and durability, while maintaining high selectivity for trace-level sample analysis.Our group focuses on single-molecule detection as a promising approach for space-compatible biosensing. We have developed a technique using nanogap electrodes formed by mechanically breaking metal nanowires. This setup allows the measurement of tunneling current through individual molecules without the need for molecular probes. Its minimal sensing area makes it especially suited for the constraints of space environments.While single-molecule detection is highly advantageous for trace analysis, it faces challenges in molecular selectivity due to variations in conductance signals from differing junction structures. In this presentation, I will outline our recent efforts to enhance selectivity in single-molecule sensing, including the identification of nucleic acids and amino acids, and detection in complex sample environments. I will also discuss progress toward integrating this technology into spacecraft for in situ molecular analysis during space missions.