Presentation Information
[10a-C309-6]Response of Cardiac Cells to Mechanical Stimulation Using a Real-Time Feedback System
〇Arisa Mizutani1, Ayaka Namiki1, Yuto Sei1, Miina Kitagawa1, Yuuta Moriyama1, Toshiyuki Mitsui1 (1.Aogaku Univ.)
Keywords:
cardiac muscle cells
Mechanical stimulation of autonomously beating single cardiomyocytes is known to induce excitation. This suggests that local mechanical stimulation may also regulate the beating rhythm and propagation in cardiomyocyte assemblies, with responses depending on the phase of stimulation within the beating cycle. In this study, we developed a feedback system that enables real-time monitoring of beating activity and phase-controlled mechanical stimulation. We report changes in inter-beat intervals and propagation direction in response to stimulation, as well as alterations in cell proliferation, differentiation, and morphology induced by long-term stimulation.