Presentation Information

11:00 AM - 11:15 AM JST(2:00 AM - 2:15 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[10a-C309-8]Analysis of Membrane Electrical Properties and Electroporation Pore Dynamics in Hydrogen Peroxide-Induced Senescent Cells

〇(M2)JIAJUN YU¹, IPPEI YAGI¹, SATOSHI UCHIDA¹ (1.Tokyo Metropolitan Univ.)

Keywords:

Auto Patch-clamp technique,Membrane electrical properties,Cellular senescence

We evaluated membrane electrical properties and post-EP pore dynamics in H₂O₂-induced senescent cells using AutoPatchClamp. In the 1000 μM group, membrane capacitance increased, membrane resistance and breakdown threshold decreased, and pore opening was accelerated with delayed recovery and larger residual pore radius.

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