[10a-E204-1~10] 2.4 Life Sciences, Medical applications, Space and Earth Environment, Radiation Education

10:15 AM - 10:30 AM JST(1:15 AM - 1:30 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[10a-E204-5] In Vivo Imaging of Gold Nanoparticles with Multiple Particle Sizes Using Photon-Counting CT for Tumor Detection

〇(M2)Yu Furuta¹, Arimoto Makoto¹, Fitri Lucyana¹, Syuma Midorikawa¹, Hiroki Kawashima¹, Satoshi Kobayashi¹, Kenichiro Okumura¹, Naoki Ohno¹, Asuka Mizutani¹, Minori Oshima¹, Kazuhiro Murakami², Jun Kataoka³, Takahiro Ro³, Ryotaro Minagawa³, Shinsuke Terazawa⁴, Yuta Maeno⁴ (1.Kanazawa Univ., 2.Ishikawa Pref. Univ., 3.Waseda Univ., 4.Proterial Ltd.)

Keywords:

photon-counting CT,Multi-pixel Photon Counter,gold nanoparticle (AuNP)

In this study, we evaluated the effects of differences in gold nanoparticle (AuNP) particle sizes on in vivo dynamics and tumor accumulation, using a photon-counting CT (PC-CT) system developed by combining a fast scintillator (YGAG:Ce) and a SiPM. Following the administration of 1.9 nm and 15 nm AuNPs to subcutaneous tumor-bearing mice and subsequent time-course imaging, we confirmed clear differences in accumulation changes over time and final in-vivo accumulation amounts depending on the particle size. These findings demonstrate the usefulness of PC-CT in tumor detection, and we report the overview of our experiments and detailed analytical results.