Presentation Information
[11a-PA1-17]Influence of Lipid Membrane-Modification on Extracellular Vesicle Detection Waveforms in Nanopore Sensing
〇Chisae Kaji1,2, Kaoru Hiramoto2,3, ayumi Hirano-Iwata1,2,4 (1.Tohoku Univ., 2.RIEC., 3.FRIS., 4.AIMR.)
Keywords:
Nanopore Sensing,Waveform Analysis
In solid-state nanopore sensing, we have successfully enhanced the capture rate and modulated the translocation time of milk exosomes by modifying nanopipettes with lipid membranes. This presentation aims to elucidate how these characteristic changes affect particle translocation behavior. To this end, we comprehensively analyzed the ionic current waveforms during target translocation across different nanopipettes with systematically varied surface charges and fluidities of the coating lipids, thereby discussing the impact of nanopore properties on particle driving forces.