Presentation Information
[11a-PA4-11]High-fidelity biological phantoms for cancer detection using circularly polarized light scattering
〇Mike Raj Maskey1, Koki Kasama1, Momoka Yamaguchi1, Iori Maeda2, Nozomi Nishizawa1 (1.Sch. of Sci., Kitasato Univ., 2.Grad. Sch. of Med. Sci., Kitasato Univ.)
Keywords:
Circularly polarized light,Optical biopsy,Light scattering
Cancer tissue assessment based on the depolarization of circularly polarized light caused by scattering in biological tissues has the potential to be applied to the estimation of tumor invasion depth. To systematically validate this approach, we have previously investigated bilayer tissue phantoms with controlled particle size only. In this study, we developed a high-fidelity tissue phantom that mimics both particle size and mean free path of cancerous and healthy tissues respectively. As a result, we successfully reproduced polarization scattering phenomena in biological tissues in a manner that more closely resembles in vivo conditions.