Presentation Information
[8a-C214-6]Molecular Transport Control in Solid-State Nanopore Sensing by Pressure-Driven Flow
〇Shu Takahashi1, Hirohito Yamazaki1, Ryo Nakagawa1 (1.Nagaoka Univ. of Tech.)
Keywords:
Solid-State Nanopores,Single-Molecule Detection,Pressure Gradient
Nanopore sensing is a highly sensitive and high-resolution single-molecule analytical technique that enables label-free detection of biomolecules. This technique is primarily driven by electrophoretic force based on ionic current measurements; therefore, it is difficult to comprehensively detect and characterize fragmented proteins because of their heterogeneous charge states. To address this limitation, we propose a protein identification method that introduces pressure-driven flow as a second driving force. In this presentation, we report the effects of pressure-driven flow on the detection of DNA and peptides.