[8p-C309-1~16] 12.7 Biomedical Engineering and Biochips

4:45 PM - 5:00 PM JST(7:45 AM - 8:00 AM UTC)Presentation by Applicant for JSAP Young Scientists Presentation Award

[8p-C309-11] Deep-brain neural recording in mouse using a low-invasive 5-μm-diameter microneedle electrode

〇Eisuke Yonezawa¹, Koji Yamashita¹, Sayaki Shimizu¹, Rika Numano¹, Kowa Koida^1,2, Takeshi Kawano¹ (1.Toyohashi Tech., 2.Tohoku Univ.)

Keywords:

microneedle electrode,Deep-brain neural recording,low-invasive

In this study, we realized deep-brain neural recording using a low-invasive microneedle electrode. We previously proposed silicon microneedles with a tip diameter of 5 µm fabricated by the vapor–liquid–solid (VLS) growth method, achieving low-invasive electrode; however, the needle length was limited to about 400 µm, making deep-brain neural recording difficult. To address this, we propose an insertion method that uses a tungsten wire as a guide. Using the proposed method, we inserted the electrode into the mouse hippocampus and recorded hippocampus-specific neural activity, and furthermore successfully recorded hippocampal seizure activity during induced epileptic seizures.