Presentation Information
[9a-E202-5]Detection of Small-Mass Medicines Using a Portable Nuclear Quadrupole Resonance Spectrometer
〇Yui Otagaki1, Yuki Hiramatsu1, Akira Yoshida1, Hiroshi Murata1 (1.Mie Univ.)
Keywords:
nuclear quadrupole resonance,portable spectrometer,medicines authentication
Counterfeit medicines are a serious threat to human health. Therefore, the technique to detect counterfeit medicines at mid-supply chain or point-of-dispensing is essential.
Nuclear quadrupole resonance (NQR) is a kind of magnetic resonance phenomena that detects the interaction between the nuclear spins and the electric field gradients inside the substance by irradiating RF magnetic field at the unique frequency according to the target. As the frequency used for NQR can penetrate most of the surface coatings of the medicines, NQR has the potential to be applied to medicines authentication because of its high specificity and ease of sample preparation.
In this presentation, we will report on our developed portable and highly-sensitive NQR spectrometer. The results showed that the developed system can quantitatively detect hexamethylenetetramine (HMT) samples in the range of 10-50mg. Mixture of HMT 10mg and starch was also tested to show the versatility of the spectrometer.
Nuclear quadrupole resonance (NQR) is a kind of magnetic resonance phenomena that detects the interaction between the nuclear spins and the electric field gradients inside the substance by irradiating RF magnetic field at the unique frequency according to the target. As the frequency used for NQR can penetrate most of the surface coatings of the medicines, NQR has the potential to be applied to medicines authentication because of its high specificity and ease of sample preparation.
In this presentation, we will report on our developed portable and highly-sensitive NQR spectrometer. The results showed that the developed system can quantitatively detect hexamethylenetetramine (HMT) samples in the range of 10-50mg. Mixture of HMT 10mg and starch was also tested to show the versatility of the spectrometer.