Presentation Information
[9p-E301-7]Mechanobiology-Based Hair Growth Using Non-contact Ultrasound Stimulation
〇Hiroya Takada1 (1.Nippon Medical Sch. Next-Gen. Mechano-Bio Med. Program)
Keywords:
mechanobiology,non-contact ultrasound,hair growth
Hair follicles and scalp vasculature are mechanosensitive tissues that respond to physical stimuli through mechanotransduction. We developed a novel hair growth therapy using a proprietary non-contact ultrasound cyclic compression stimulation device and evaluated its biological effects in clinical and experimental studies. In monitor patients treated with non-contact stimulation, hair growth promotion was observed without the use of pharmaceuticals, even at a treatment frequency of only one to two sessions per month. Combination treatment with topical minoxidil showed no evidence of interference between the two modalities. In a mouse model, activation of SUR2B, a component of ATP-sensitive potassium (KATP) channels, was observed, suggesting a potential mechanistic pathway shared with hair growth signaling. These findings indicate that non-contact ultrasound stimulation may provide a safe, non-invasive, and drug-free therapeutic option for hair loss. This technology represents a novel application of mechanobiology and mechanotherapy for promoting hair regeneration.