[9p-E301-1~10] Learning from life, transcending life: Total Biomimetics Connecting Materials, Medicine, and Social Implementation

5:25 PM - 6:05 PM JST(8:25 AM - 9:05 AM UTC)

[9p-E301-8] Research and Development of Redox Nanomedicine: Challenges Toward Clinical Translation

〇Aiki Marushima^1,3, Yukio Nagasaki², Hiroshi Yamagami¹, Eiichi Ishikawa¹, Yuji Matsumaru¹ (1.Institute of Medicine, Univ. of Tsukuba, 2.Institute of Pure and Applied Sciences, Univ. of Tsukuba, 3.CrestecBio Inc.)

Keywords:

nanoparticle,stroke,redox

Redox regulation targeting reactive oxygen species has emerged as a promising therapeutic strategy for ischemic and other oxidative stress–related diseases. We have developed redox nanoparticles composed of amphiphilic polymers conjugated with nitroxide radicals that self-assemble into polymeric micelles. These nanoparticles exhibit potent ROS-scavenging activity and prolonged tissue retention, demonstrating therapeutic efficacy in mouse and non-human primate models of ischemic stroke. In this presentation, I will discuss the development of these nanomaterials, their translation into drug candidates, and efforts toward clinical and commercial implementation through a university spin-off venture.