Presentation Information
[E2-2]Short-term Outcomes of NOSES vs Conventional Laparoscopic Surgery in CRC
Xu Guan (Department of colorectal cancer surgery, the Second Affiliated Hospital of Harbin Medical University)
Abstract: This multicenter RCT compared NOSES (n=234) with conventional laparoscopic surgery (CLS, n=235) in patients with stage cT1-3N0-2M0 sigmoid/upper rectal cancer. NOSES demonstrated superior recovery outcomes: significantly shorter time to first flatus (48 vs 50h, P<0.001), lower pain scores at 24/48/72h (all P<0.001), and reduced opioid analgesic requirement (17.5% vs 37.4%, P<0.001). While overall complication rates trended lower (12.0% vs 18.3%, P=0.056), major complications (Clavien-Dindo &geIII) were comparable (4.3% vs 5.1%, P=0.682). No differences were observed in oncologic safety measures including lymph node harvest (median 22 vs 21, P=0.312) or resection margins. Quality of life assessments using EQ-5D-5L showed consistent superiority for NOSES at 1/3/6 months postoperatively (all P<0.05), particularly in pain/discomfort and anxiety/depression domains. These robust findings confirm NOSES as a safe, minimally invasive alternative offering meaningful clinical benefits for appropriately selected colorectal cancer patients.