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Optically manipulating intracellular phenomena using photochromism: Photoreversible control of protein dimerization under confocal microscopy

There has been growing interest in artificially manipulating cellular functions, particularly through synthetic molecules in chemical biology and light-responsive proteins in optogenetics. Related with these technologies, the presenter developed "Photochromic CID Technology" (CID: Chemically Induced Dimerization). This technology employs synthetic compounds that exhibit photochromism—a property where color or shape changes in response to light—to rapidly and reversibly control the dimerization of universal tag-fused proteins in cells, enabling precise manipulation of various intracellular phenomena. In the seminar, he will present several applications, such as regulation of intracellular signal transduction and protein assembly. References： 1. T. Mashita et al., ChemBioChem 2019, 20, 1382. 2. T. Mashita et al., Nat. Chem. Biol. 2024, https://doi.org/10.1038/s41589-024-01654-w

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[2BT-06-01]Optically manipulating intracellular phenomena using photochromism: Photoreversible control of protein dimerization under confocal microscopy

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