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The utilization of NAMs (New Approach Methodologies) and MPS (Microphysiological Systems) using human-derived neural cells and international trends.

The FDA Modernization Act 2.0 has been enacted, promoting the international use of human-derived cultured cells for compound evaluation in chemical assessments and drug development. New Approach Methods (NAMs), which aim to avoid the use of laboratory animals and provide information on the toxicity and risk assessment of chemicals, are being actively adopted. In this context, the Organization for Economic Co-operation and Development (OECD) has proposed 17 in vitro assays for developmental neurotoxicity assessment of chemicals. In this luncheon seminar, I would like to introduce the utilization of NAMs in the nervous system for compound evaluation, including pharmaceuticals, as well as the use of Microphysiological Systems (MPS). Additionally, I will present data and international trends related to the use of human-derived central nervous system, peripheral nervous system, and brain organoids.<br>

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[2BT-13-01]The utilization of NAMs (New Approach Methodologies) and MPS (Microphysiological Systems) using human-derived neural cells and international trends.

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