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Dynamic Structure of the DOCK5/ELMO1 Guanine Nucleotide Exchange Factor Complex Revealed by Cryo-EM

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Co-hosted by: Grant-in-Aid for Challenging Research (Pioneering), Searching druggable target sites by developing refined molecular dynamic simulations

In this symposium, we would like to present efforts to understand and predict the structure and affinity of disease-associated proteins and/or ligands through structure analysis and computational simulation. In order to understand the biological processes and develop novel therapeutic strategies, we have studied and developed high-resolution structure analysis and molecular dynamic protein structure simulation of disease-associated proteins. In this session, each speaker will present their latest efforts to visualize and deeply understand how disease-associated proteins and the drugs interact with each other using cryo-EM analysis and/or supercomputer-based ultra-high precision molecular dynamic simulations.<br>

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[2MS-05-01]Dynamic Structure of the DOCK5/ELMO1 Guanine Nucleotide Exchange Factor Complex Revealed by Cryo-EM

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