The 47th Annual Meeting of the Molecular Biology Society of Japan

Chairman:Akira Sato(Carl Zeiss Co., Ltd.)

Chemical modification of biomolecules by synthetic probes is a powerful technique for creating useful molecular tools for biological research. For example, the selective attachment of fluorescent dyes to target proteins in cells or living animals allows various applications such as bioimaging, interaction detection, and activity regulation of proteins. In addition, direct functionalization of metabolites not directly encoded by genes, such as lipids, with synthetic probes enables dynamic analysis that cannot be achieved by conventional molecular biology-based techniques and genetic engineering. In this talk, I will introduce our recent works on in situ modification for biomolecules imaging with Zeiss microscopy and their applications in proteomics and genomics.